SRG大鼠, SRG Rats - 维通利华

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SRG Rats

品系代码：

415

专业名称：

Sprague Dawley-Rag2^em2heraIl2rg^em1hera/HblCrl

大鼠,免疫缺陷模型免疫学,肿瘤学近交系,免疫缺陷

异种移植（人源器官、肿瘤组织等）、肿瘤生物学、肿瘤学、免疫学、皮肤学

品系来源

应用特性

价格规格

应用文献

品系来源

SRG大鼠是在SD（Sprague Dawley）大鼠上敲除Rag2和Il2rγ基因的功能性片段，使得动物缺失T、B和NK细胞，表现为重度免疫缺陷。

2016年Hera Biolabs从Transposagen引种；

2021年Charles River Laboratories从Hera Biolabs引种；

✈ 2022年维通利华从Charles River引入该品系核心群。2024年重新从Charles River引入核心群。

☑ 拓展阅读：“重”磅新品 | 重度免疫缺陷大鼠SRG的来源、特点与应用优势

☑ 更多裸鼠品系：BALB/c Nude小鼠，CD-1® Nude小鼠，NU/NU小鼠，裸大鼠

应用特性

研究用途：异种移植（人源器官、肿瘤组织等）、肿瘤生物学、肿瘤学、免疫学、皮肤学

特性：

重度免疫缺陷：Rag2和Il2rγ基因缺失导致T、B、NK细胞缺失，动物胸腺和脾脏严重萎缩
支持多种CDX模型建立，部分细胞系移植效率更高（如VCaP，H358和HCT116）
PDX模型优势显著：移植成功率高，迅速建立、扩大肿瘤组织样本库，同时高度还原患者肿瘤组织学特点
动物体型大：

可承受更大的肿瘤负荷，获得更多生物样本量，同时进行多种分析实验

寿命长，支持长期实验

支持在同一只动物上进行连续采样，对动物状态影响小，获得数据连续性好，降低个体差异的潜在影响

降低采血、插管等外科实验操作难度，提高成功率

保障动物福利，支持3Rs原则（替代、减少和优化）

价格规格

品系代码	品系名称	日/周龄	性别	VAF/SPF级	Elite/SPF级
415	SRG Rat	3-5周	雄/雌		1580
415	SRG Rat	6-8周	雄/雌		1680
415	SRG Rat	9-10周	雄/雌		1780

*以上规格与价格自2025年1月1日至2025年12月31日有效。

应用文献

SRG Publications

Authors	Year	Paper Title	Keywords
D Begemann, et al.	2024	The SRG Rat, an immunodeficient model for orthotopic glioblastoma, diffuse intrinsic pontine glioma (DIPG) PDX, and intracranial metastatic breast cancer PDX tumors	orthotopic glioblastoma， SRG Rat, PDX,
GRACE WALTON, et al.	2024	The Highly Immunodeficient SRG Rat for Modeling Diabetes	STZ, DIO, diet-induced obesity (DIO) 2 Diabetes, IPGTT
Disi An, et al.	2024	LTβR Agonism Promotes Antitumor Immune Responses via Modulation of the Tumor Microenvironment	LTβR, CTLA4, HEV/TLS
Carine Ciron, et al.	2024	LIS22, a first in class polyclonal antibody immunotherapy in T cell blood cancers	LIS22, T Cell hematologic malignancies, T1301, Jurkat, CDC, ADCP, ADCC
Kyle Draheim, et al.	2024	Development and evaluation of subcutaneous and orthotopic PC3M metastatic prostate cancer xenograft model in SRG rats for therapeutic assessment	prostate cancer, PC3M-luc cells, orthotopically， subcutaneously
Stephen J. Gadomski, et al.	2024	Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy	BMP signaling, Human bone marrow stromal cells/skeletal stem cells (hBMSCs/SSCs) , hyaluronic acid-coated fibrin microbeads (HyA-FMBs), articular-like cartilage
Ami Yamamoto, et al.	2023	Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7	necrotic core, angiopoietin-like 7, circulating tumor cells, metastasis, breast cancer
Diane Begemann, et al.	2023	In vivo subcutaneous and orthotopic cancer xenograft modeling in the SRG immunodeficient rat	lung and liver orthotopic cancers.
Caitlin M. O'Connor, et al.	2022	Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma	Uterine serous carcinoma, PP2A gene, RNAi
Agarwal, Y. et al	2020	Development of Humanized Mouse and Rat Models with Full-thickness Human Skin and Autologous Immune Cells	Xeno-transplantation, skin infection, humanized
Noto FK. et al	2020	The SRG Rat, a Sprague-Dawley Rag2/Il2rg Double-knockout Validated for Human Tumor Oncology Studies	PDX, CDX, Oncology
Suriyan Ponnusamy. et al.	2019	Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer	Xenograft, efficacy evaluation, Androgen receptor, prostate cancer, oncology
Maulhardt, H. A. et al.	2019	Local Injection of Submicron Particle Docetaxel is Associated with Tumor Eradication, Reduced Systemic Toxicity and an Immunologic Response in Uro-Oncologic Xenografts	Docetaxel, NanoDoce®, efficacy evaluation, genitourinary oncology